Background: The Immediate loading (IL) protocol has gained increased popularity among surgeons in the last decade.Objectives: This study aimed to evaluate the clinical performance of Microtextured single-tooth implants using IL protocol six months after loading.Patients and Methods: In this case series, SwissPlus implants (Zimmer Dental Inc, Carlsbad CA, USA) which was straight, self-tapping, 12 mm length and 4.1 mm diameter, were inserted into both jaws and single edentulous sites with clinically and radiologically healed bone by an experienced surgeon. In the test group (with IL protocol), one week after the surgery, the provisional crowns and abutments were loaded, and definitive restorations were delivered three months postoperatively. The factors including pain, mobility, probing depth (PD), bleeding on probing (BOP) and marginal bone loss (MBL) were investigated six months after the IL. The Mc Nemar and Wilcoxon tests were used for nominal variables and the paired ttest was also used for quantitative variables.Results: Twenty-five implants were placed in 23 patients at Dental School, Shahed University, Tehran, Iran. The test group included 15 patients (16 implants) treated with immediately loaded single-tooth implants. The survival rate was 100% in both groups. In test, a significant reduction was measured in PD and pain; moreover, no statistically significant difference was noted between follow-ups with regard to mobility and BOP. The mean PD values six months for test and nine months for control after installation were 2.548 mm and 2.694 mm, respectively. Marginal bone loss was significantly decreased in the test group between the follow-ups.Conclusions: Consequently, this study shows promising results for IL of single implants, and it can be considerable that treatment with Microtextured surface implants is a predictable and appropriate method of treatment.